Effects of Lactobacillus casei supplementation on disease activity and inflammatory cytokines in rheumatoid arthritis patients: a randomized double‐blind clinical trial
Identifieur interne : 001067 ( Main/Exploration ); précédent : 001066; suivant : 001068Effects of Lactobacillus casei supplementation on disease activity and inflammatory cytokines in rheumatoid arthritis patients: a randomized double‐blind clinical trial
Auteurs : Beitullah Alipour [Iran] ; Aziz Homayouni-Rad [Iran] ; Elnaz Vaghef-Mehrabany [Iran] ; Sakineh Khatoun Sharif [Iran] ; Leila Vaghef-Mehrabany [Iran] ; Mohammad Asghari-Jafarabadi [Iran] ; Mohammad Reza Nakhjavani [Iran] ; Javad Mohtadi-Nia [Iran]Source :
- International Journal of Rheumatic Diseases [ 1756-1841 ] ; 2014-06.
Abstract
Aim: The present study aimed at investigating the effects of Lactobacillus casei 01 supplementation on symptoms and inflammatory biomarkers of rheumatoid arthritis (RA) in women. Method: In this randomized double‐blind clinical trial, female patients with established RA for more than 1 year, 20–80 years of age and body mass index (BMI) lower than 40, who followed stable medication for 3 months prior to the supplementation, were randomly allocated to receive either one capsule containing 108 colony forming units (CFU) of L. casei 01, or a placebo for 8 weeks; allocation was stratified by BMI and menopausal status. Disease activity score‐28 (DAS28) was calculated, European League Against Rheumatism (EULAR) response was evaluated and the cytokines, interleukin (IL)‐1β, IL‐6, IL‐10, IL‐12 and tumor necrosis factor (TNF)‐α were measured. Results: Thirty patients were recruited in each group; 22 and 24 patients were analyzed in the probiotic and placebo groups, respectively. L. casei 01 supplementation decreased serum high‐sensitivity C‐reactive protein (hs‐CRP) levels, tender and swollen joint counts, global health (GH) score and DAS28 (P < 0.05). More patients in the L. casei 01 group had moderate response to the treatment, based on the EULAR criteria, at the end of the study (P < 0.01). At the end of the study, a significant difference was observed between the two groups for IL‐10, IL‐12 and TNF‐α changes through the study course (P < 0.05), in favor of the probiotic group. No adverse effects were reported for the intervention. Conclusion: Probiotic supplementation may be an appropriate adjunct therapy for RA patients and help alleviate symptoms and improve inflammatory cytokines.
Url:
DOI: 10.1111/1756-185X.12333
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wicri:level="1"><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Community Nutrition, Tabriz University of Medical Sciences, Tabriz</wicri:regionArea><wicri:noRegion>Tabriz</wicri:noRegion></affiliation></author><author><name sortKey="Homayouni Ad, Aziz" sort="Homayouni Ad, Aziz" uniqKey="Homayouni Ad A" first="Aziz" last="Homayouni-Rad">Aziz Homayouni-Rad</name><affiliation wicri:level="1"><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Food Science and Technology, Tabriz University of Medical Sciences, Tabriz</wicri:regionArea><wicri:noRegion>Tabriz</wicri:noRegion></affiliation></author><author><name sortKey="Vaghef Ehrabany, Elnaz" sort="Vaghef Ehrabany, Elnaz" uniqKey="Vaghef Ehrabany E" first="Elnaz" last="Vaghef-Mehrabany">Elnaz Vaghef-Mehrabany</name><affiliation wicri:level="1"><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Nutrition, Biochemistry and Diet Therapy, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz</wicri:regionArea><wicri:noRegion>Tabriz</wicri:noRegion></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Iran</country></affiliation></author><author><name sortKey="Sharif, Sakineh Khatoun" sort="Sharif, Sakineh Khatoun" uniqKey="Sharif S" first="Sakineh Khatoun" last="Sharif">Sakineh Khatoun Sharif</name><affiliation wicri:level="1"><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Rheumatology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz</wicri:regionArea><wicri:noRegion>Tabriz</wicri:noRegion></affiliation></author><author><name sortKey="Vaghef Ehrabany, Leila" sort="Vaghef Ehrabany, Leila" uniqKey="Vaghef Ehrabany L" first="Leila" last="Vaghef-Mehrabany">Leila Vaghef-Mehrabany</name><affiliation wicri:level="1"><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Nutrition, Faculty of Nutrition and Diet Therapy, Tehran University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Asghari Afarabadi, Mohammad" sort="Asghari Afarabadi, Mohammad" uniqKey="Asghari Afarabadi M" first="Mohammad" last="Asghari-Jafarabadi">Mohammad Asghari-Jafarabadi</name><affiliation wicri:level="1"><country xml:lang="fr">Iran</country><wicri:regionArea>Traffic Injury Prevention Research Center, Faculty of Health, Tabriz University of Medical Sciences, Tabriz</wicri:regionArea><wicri:noRegion>Tabriz</wicri:noRegion></affiliation></author><author><name sortKey="Nakhjavani, Mohammad Reza" sort="Nakhjavani, Mohammad Reza" uniqKey="Nakhjavani M" first="Mohammad Reza" last="Nakhjavani">Mohammad Reza Nakhjavani</name><affiliation wicri:level="1"><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Rheumatology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz</wicri:regionArea><wicri:noRegion>Tabriz</wicri:noRegion></affiliation></author><author><name sortKey="Mohtadi Ia, Javad" sort="Mohtadi Ia, Javad" uniqKey="Mohtadi Ia J" first="Javad" last="Mohtadi-Nia">Javad Mohtadi-Nia</name><affiliation wicri:level="1"><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Food Science and Technology, Tabriz University of Medical Sciences, Tabriz</wicri:regionArea><wicri:noRegion>Tabriz</wicri:noRegion></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Iran</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">International Journal of Rheumatic Diseases</title><title level="j" type="alt">INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES</title><idno type="ISSN">1756-1841</idno><idno type="eISSN">1756-185X</idno><imprint><biblScope unit="vol">17</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="519">519</biblScope><biblScope unit="page" to="527">527</biblScope><biblScope unit="page-count">9</biblScope><date type="published" when="2014-06">2014-06</date></imprint><idno type="ISSN">1756-1841</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1756-1841</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Aim: The present study aimed at investigating the effects of Lactobacillus casei 01 supplementation on symptoms and inflammatory biomarkers of rheumatoid arthritis (RA) in women. Method: In this randomized double‐blind clinical trial, female patients with established RA for more than 1 year, 20–80 years of age and body mass index (BMI) lower than 40, who followed stable medication for 3 months prior to the supplementation, were randomly allocated to receive either one capsule containing 108 colony forming units (CFU) of L. casei 01, or a placebo for 8 weeks; allocation was stratified by BMI and menopausal status. Disease activity score‐28 (DAS28) was calculated, European League Against Rheumatism (EULAR) response was evaluated and the cytokines, interleukin (IL)‐1β, IL‐6, IL‐10, IL‐12 and tumor necrosis factor (TNF)‐α were measured. Results: Thirty patients were recruited in each group; 22 and 24 patients were analyzed in the probiotic and placebo groups, respectively. L. casei 01 supplementation decreased serum high‐sensitivity C‐reactive protein (hs‐CRP) levels, tender and swollen joint counts, global health (GH) score and DAS28 (P < 0.05). More patients in the L. casei 01 group had moderate response to the treatment, based on the EULAR criteria, at the end of the study (P < 0.01). At the end of the study, a significant difference was observed between the two groups for IL‐10, IL‐12 and TNF‐α changes through the study course (P < 0.05), in favor of the probiotic group. No adverse effects were reported for the intervention. Conclusion: Probiotic supplementation may be an appropriate adjunct therapy for RA patients and help alleviate symptoms and improve inflammatory cytokines.</div></front></TEI><affiliations><list><country><li>Iran</li></country></list><tree><country name="Iran"><noRegion><name sortKey="Alipour, Beitullah" sort="Alipour, Beitullah" uniqKey="Alipour B" first="Beitullah" last="Alipour">Beitullah Alipour</name></noRegion><name sortKey="Asghari Afarabadi, Mohammad" sort="Asghari Afarabadi, Mohammad" uniqKey="Asghari Afarabadi M" first="Mohammad" last="Asghari-Jafarabadi">Mohammad Asghari-Jafarabadi</name><name sortKey="Homayouni Ad, Aziz" sort="Homayouni Ad, Aziz" uniqKey="Homayouni Ad A" first="Aziz" last="Homayouni-Rad">Aziz Homayouni-Rad</name><name sortKey="Mohtadi Ia, Javad" sort="Mohtadi Ia, Javad" uniqKey="Mohtadi Ia J" first="Javad" last="Mohtadi-Nia">Javad Mohtadi-Nia</name><name sortKey="Mohtadi Ia, Javad" sort="Mohtadi Ia, Javad" uniqKey="Mohtadi Ia J" first="Javad" last="Mohtadi-Nia">Javad Mohtadi-Nia</name><name sortKey="Nakhjavani, Mohammad Reza" sort="Nakhjavani, Mohammad Reza" uniqKey="Nakhjavani M" first="Mohammad Reza" last="Nakhjavani">Mohammad Reza Nakhjavani</name><name sortKey="Sharif, Sakineh Khatoun" sort="Sharif, Sakineh Khatoun" uniqKey="Sharif S" first="Sakineh Khatoun" last="Sharif">Sakineh Khatoun Sharif</name><name sortKey="Vaghef Ehrabany, Elnaz" sort="Vaghef Ehrabany, Elnaz" uniqKey="Vaghef Ehrabany E" first="Elnaz" last="Vaghef-Mehrabany">Elnaz Vaghef-Mehrabany</name><name sortKey="Vaghef Ehrabany, Elnaz" sort="Vaghef Ehrabany, Elnaz" uniqKey="Vaghef Ehrabany E" first="Elnaz" last="Vaghef-Mehrabany">Elnaz Vaghef-Mehrabany</name><name sortKey="Vaghef Ehrabany, Leila" sort="Vaghef Ehrabany, Leila" uniqKey="Vaghef Ehrabany L" first="Leila" last="Vaghef-Mehrabany">Leila Vaghef-Mehrabany</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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